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Unconjugated estriol (E3) is a form of estrogen, which is biologically active. It is exclusively produced during pregnancy, unlike other estrogens. Unconjugated Estriol test is included as part of triple marker and quadruple marker test for antenatal screening for monitoring fetal development and knowing the risk of pregnancy-related complications like premature labor or fetal distress. The level of unconjugated estriol rises during pregnancy, especially in the first trimester. Low levels of unconjugated estriol indicate Down and trisomy-18 syndromes, and neural tube defects. High levels of estriol are observed in case of congenital adrenal hyperplasia.
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